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Bioprocess design guided by in situ substrate supply and product removal: Process intensification for synthesis of (S)-1-(2-chlorophenyl)ethanol

机译：以原位底物供应和产品去除为指导的生物工艺设计：（S）-1-（2-氯苯基）乙醇合成的工艺强化

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► o-Chloroacetophenone and its reduction product are highly toxic to enzymes and cells. ► Properties of substrate and product guided comprehensive bioprocess engineering. ► Substrate supply and product removal were optimized. ► Mass transfer limitations were overcome by cell permeabilization. ► (S)-1-(2-chlorophenyl)ethanol was obtained in high optical purity and yield.

机译：►邻氯苯乙酮及其还原产物对酶和细胞有剧毒。 ►基质和产品的特性指导了全面的生物工艺工程。 ►优化了基材供应和产品去除。 ►细胞透化克服了传质限制。 ►以高光学纯度和产率获得（S）-1-（2-氯苯基）乙醇。

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Schmölzer, Katharina; Mädje, Katharina; Nidetzky, Bernd; Kratzer, Regina;
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年度 2012
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正文语种 en
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1. Bioprocess design guided by in situ substrate supply and product removal: Process intensification for synthesis of (S)-1-(2-chlorophenyl)ethanol [J] . Schm?lzer K., M?dje K., Nidetzky B., Bioresource Technology: Biomass, Bioenergy, Biowastes, Conversion Technologies, Biotransformations, Production Technologies . 2012,第Null期

机译：以原位底物供应和产品去除为指导的生物工艺设计：（S）-1-（2-氯苯基）乙醇合成的工艺强化
2. Synthesis of the methanesulfonates of alpha-(4-chlorophenyl)-alpha-[1-(2-chlorophenyl)ethenyl]-1H-1,2,4-triazole -1-ethanol and alpha-[1-(2-chlorophenyl)ethenyl]-alpha-(2,4-difluorophenyl)-1H-1,2,4-tria zole-1-ethanol, alpha styryl carbinol antifunga [J] . Pesti JA., Lauritsen MD., Kauffman GS., Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 1998,第1期

机译：α-（4-氯苯基）-α-[1-（2-氯苯基）乙烯基] -1H-1,2,4-三唑-1-乙醇和α-[1-（2-氯苯基）的甲磺酸盐的合成乙烯基]-α-（2,4-二氟苯基）-1H-1,2,4-三唑-1乙醇，α苯乙烯基甲醇抗真菌剂
3. Scale-up and intensification of (S)-1-(2-chlorophenyl)ethanol bioproduction: Economic evaluation of whole cell-catalyzed reduction of o-Chloroacetophenone [J] . Eixelsberger T., Woodley J.M., Nidetzky B., Biotechnology and Bioengineering . 2013,第8期

机译：（S）-1-（2-氯苯基）乙醇生物生产的规模化和集约化：全细胞催化还原邻氯苯乙酮的经济评价
4. OPPORTUNITIES FOR THE BIOPROCESS INTENSIFICATION OF THE BIOSYNTHESIS OF NATURAL PRODUCTS FROM CYANOBACTERIA [C] . Adam M. Burja, Eliane Abou-Mansour, Bernard Banaigs, The American Institute of Chemical Engineers 2001 Annual Meeting, Nov 5-9, 2001, Reno, NV . 2001

机译：蓝藻天然产物生物合成的生物过程强化的机会
5. Consolidated bioprocessing and liquid hot water pretreatment for the production of ethanol from cellulosic substrates. [D] . van Walsum, Gerard Peter. 1998

机译：合并的生物处理和液体热水预处理，用于从纤维素底物中生产乙醇。
6. Bioprocess design guided by in situ substrate supply and product removal: Process intensification for synthesis of (S)-1-(2-chlorophenyl)ethanol [O] . Katharina Schmölzer, Katharina Mädje, Bernd Nidetzky, -1

机译：以原位底物供应和产品去除为指导的生物工艺设计：（S）-1-（2-氯苯基）乙醇合成的工艺强化
7. Process intensification of the enzymatic cascade to metaraminol with integrated in‐situ liquid‐liquid product removal [O] . L. Grabowski, K. Mack, M. Doeker, 2020

机译：用集成的原位液 - 液产物去除，将酶级联的酶级联的加强强化
8. Survey and Down-Selection of Acid Gas Removal Systems for the Thermochemical Conversion of Biomass to Ethanol with a Detailed Analysis of an MDEA System. Task 1: Acid Gas Removal Technology Survey and Screening for Thermochemical Ethanol Synthesis. Task 2: Detailed MDEA Process Analysis [R] . 2011

机译：通过详细分析mDEa系统，对生物质热化学转化为乙醇的酸性气体去除系统进行了调查和下调。任务1：酸性气体去除技术调查和筛选热化学乙醇合成。任务2：详细的mDEa过程分析

Bioprocess design guided by in situ substrate supply and product removal: Process intensification for synthesis of (S)-1-(2-chlorophenyl)ethanol

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